corazonescontralaleucemia: September 2013

Sunday, September 22, 2013

How to watch Michigan State vs. notre Dame 2013: Preview, TV schedule, odds and more

The Spartans and Fighting Irish renew their longtime rivalry this Saturday at Notre Dame Stadium.

In one of the sneaky good rivalries of the 21st century, Notre Dame and Michigan State square off in an afternoon tilt in South Bend on Saturday afternoon.

The two teams have had nine games decided by a single possession since 2000, and who can forget the 44-41 Notre Dame comeback victory of 2006 and the purely epic Michigan State radio meltdown it precipitated?

There may be no such collapse and meltdown this season, but a matchup of two of the top defenses in the nation should provide plenty of hard hits and drama for sixty solid minutes.

The numbers

Rankings and records: Notre Dame enters Week 4 at 2-1, ranked 22nd in the AP poll and 21st in the USA Today Coaches Poll. Undefeated Michigan State is the top team also receiving votes in the AP and sits at 24th in the Coaches Poll.

Vegas: Notre Dame is favored by 4.5 points, and the over/under is 42 points.

Weather: It's perfect football weather in South Bend this Saturday, as it'll be clear with kickoff temperatures right around 70 degrees and staying in the upper 60s for the game.

Three names to know

Connor Cook is Michigan State's starting quarterback this week after shredding Youngstown State for four first-half touchdowns last week. He has emerged from the Spartans' four-man QB race as the lone starter on the depth chart, but this'll be his first true test as the leader of the offense.

Making Cook's day difficult will be Notre Dame defensive end Stephon Tuitt, a 6'7, 312-pound first-team All-American who should terrorize Michigan State's tackles over the course of the game. Tuitt is a matchup nightmare with the size to dominate smaller linemen and the speed to get around mountains ... and he doesn't miss tackles.

Meanwhile, there's no shortage of playmakers on the Spartans' defense, but MSU defensive end Shilique Calhoun has been a hell-raiser in the early going, collecting four turnovers and scoring three touchdowns in just three games thus far. After the first two games, Calhoun (who, again, is a defensive lineman) actually led the Spartans in scoring. He has since been supplanted by RB Jeremy Langford, but Calhoun's also a wonderful guy off the field, according to the Detroit Free-Press.

Two things at stake

For Notre Dame, a 2-2 start to the season would be tough to stomach -- especially with a brutal slate of Oklahoma-Arizona State-USC looming. The home stretch gets considerably easier from there (aside from a trip to No. 5 Stanford to finish things off), but a home loss to Michigan State could portend a five- or six-loss season. That'd be far less than ideal for a team coming off a berth in the BCS Championship Game.

Meanwhile, Michigan State absolutely needs to see good play from Cook, otherwise its QB race isn't truly settled -- and that's a recipe for disaster coming into Big Ten play. This game won't directly affect the Spartans' run for another Legends Division title, of course, but it'll go a long way in determining how likely a trip back to Indianapolis might be for coach Mark Dantonio and his crew.

How to witness

TV: This game will be on Notre Dame's station, NBC, at 3:30 p.m. ET. Announcers are Dan Hicks and Mike Mayock in the booth with Alex Flanagan on the sidelines.

Radio: Here's a list of Notre Dame's affiliates on IMG Radio, and Michigan residents can listen on the Spartan Sports Network at these stations.

Online streaming: NBC Sports will offer this game on its LiveExtra streaming service.

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Source: Celebridades24

Fernando Alonso admitted Ferrari's underwhelming qualifying result simply reflected the pace the F138 displayed throughout practice in singapore, leaving the Spaniard banking on his usual strong Sunday recovery.

The Spaniard had gone into Saturday night's qualifying session under the lights at Marina Bay having lapped a second or more lower than the respective pacesetter in each of the three practice sessions.

While Alonso claimed successive second-place finishes at Spa and Monza, Ferrari had admitted that the acid test of their recent development work would come in Singapore given the higher-downforce conditions demanded by the circuit are more indicative of the rest of the calendar.

However, after setting only the seventh-fastest Q3 time - which was compounded by outgoing team-mate Felipe Massa outqualifing him for the third time in the last five events - Alonso adopted his usual Saturday night mantra after the session.

"We were not competitive in any of the sessions this weekend unfortunately and we were struggling a little bit with the pace compared with our main competitors," he told Sky Sports F1.

Coming up on Singapore GP race day

"But in a way it's nothing new from some other weekends - qualifying struggling a little bit, Sunday improving things, and in the end getting close to the podium or on the podium.

"So tomorrow we will try to do our good Sunday again, try to score many points and see where our main competitors finish the race."

Although his runner-up finishes at the last two events had seen him re-emerge as Sebastian Vettel's closest challenger in the championship, the German's victories at both events means the Spaniard heads into Sunday's race 53 points back on his perennial rival, and after the Red Bull man's latest pole, facing the prospect of that gap only increasing.

The Spaniard nonetheless traditionally comes to the fore over the longer race distance and suggested there should be opportunities to work himself towards the podium during Sunday's gruelling 61-lap grand prix.

"It's not so clear yesterday after the long runs which tyre is the best for the race, how many stops are coming into the race," Alonso replied when asked about strategy permutations.

"So I think strategy is very open at the moment. We need to concentrate step-by-step, the first is the start, the first corner, the first lap. After that making the tyres stay alive for a little bit longer than our rivals and then we'll see [where they are].

"It's a tricky circuit in a mechanical point of view, in the physical point of view, so we must finish the race, score as many points as possible and then check what the others did."

Live on Sky Sports

Live Formula One
2013 Singapore Grand Prix
September 22, 2013 11:30am

While history - and championship position - suggests Alonso will emerge as Ferrari's strongest challenger in the race despite being outqualified by Massa again, the Brazilian's performance in beating his team leader o the third row was nonetheless timely as he strives to save his F1 career after being told by his long-time employers last week that his services won't be required for 2014.

Massa had appeared to be particularly all at sea during practice with the handling of his F138 so was delighted to turn things around.

"We changed completely the car from yesterday to today. Free Practice Three was still not perfect, we changed the car again for qualifying and actually managed to put together a great lap in Q3," he told Sky Sports F1.

"I'm very happy for how I started the weekend and for the qualifying I did. Put a great lap together in Q3 and I hope we can have a great race tomorrow."

Source: Skysports

Saturday, September 21, 2013

Trey Canard remembers the moments just before the crash.

He didn't have enough speed to the third hill, so he backed off the throttle and cleared the second one, thinking he'd just ride over the third.

After that, the memories were splotches on his consciousness: The intense pain as he woke up in a medical helicopter, bits and pieces of hazy, drug-induced conversations, wires and tubes hooked to beeping machines, worried family members looking on.

Once he was able to grasp what had happened, Canard's first thought was about how lucky he was.

A 300-pound motorcycle landed on his back and he not only survived, he was expected to make a full recovery. Once Canard pushed past the initial stages of his recovery, he set a goal.

He was going to race again.

"It's all I've ever known," Canard said.

Canard did make his way back to racing this year. Not just turning laps, either. Racing his way to top-10 finishes during the Supercross and outdoor seasons.

For those who know him, it was no surprise.

Misfortune - whether the death of his father at a young age or a series of severe injuries - has seemed to follow the rider from Elk City, Okla., throughout his life.

Canard never let allowed any of it to make him back off the throttle, beating back adversity with a combination of determination and faith.

"He's kind of stubborn," Canard's mother, Kari, said. "So I knew he'd be able to come back."

Canard's biggest setback came when he was 12.

His father, Roy, had been a huge supporter of his motocross racing and built a small track on the family's property.

One day while working on the track, Roy Canard was clearing some rocks with a tractor. When he climbed off the tractor, it somehow flipped over and the family found him pinned underneath it.

"We knew it didn't look good when we saw him," Trey said.

Canard could have abandoned racing after such a traumatic event. He had grown up riding dirt bikes with his dad and no one would have blamed him for losing his passion for the sport.

Instead, the accident pushed Canard toward motocross even more, driving him to work harder in his father's honor.

"It certainly was something that was very difficult to go through," said Canard, who turned 23 last Tuesday. "But you find a way to get through it and continue with your life. Racing was something that we did together and it just made me want to work hard and be the best I could be."

After a decorated amateur career, Canard was one of motocross' rising stars and proved it by winning the 250cc AMA Motocross title in 2010. That landed him a 450 ride, but it also started his run of injuries, including two broken femurs and a broken collarbone.

The worst of it came on Jan. 21, 2012 during a Supercross race at Dodgers Stadium in Los Angeles.

After getting a piece of sign stuck in his wheel, Canard didn't have the speed to complete a triple jump, so went for the double. Just as he started over the third hill on the ground, fellow Ryan Morais came sailing in from above. Already committed to the jump and with nowhere else to go, Morais came down on Canard, landing his back wheel on his back.

Both riders went sprawling as the crowd let out a gasp.

Morais suffered numerous injuries, including a broken back, jaw and ribs.

Canard broke three vertebrae and had to be airlifted to a local hospital.

Confusion followed; Canard because he was in shock and sedated, his family because they couldn't get any answers and were concerned about the care he was receiving.

"It was frustrating because there wasn't a lot of information being shared and we weren't sure how bad it was," Kari Canard said.

The family had Canard moved to another hospital, where he underwent surgery to take the pressure off his spinal cord and stabilize the broken vertebrae with two rods along his spine.

Then started the long rehabilitation process, from the first few days of working on range of motion to swimming and strengthening exercises. He took small steps - like being able to take out the garbage by himself or riding his bicycle - and was back on his dirt bike seven months after the accident.

Canard returned to competitive racing for the 2013 Supercross opener at Angel Stadium in Anaheim, Calif., on Jan. 5. Despite all the attention his return generated, it was like Canard had never been gone; he finished second in the main event to David Millsaps.

"I was pretty nervous, but it felt good to get back out there," Canard said. "The support I got from the other riders was pretty incredible, something I'll never forget."

Canard made it through the next race with no problem and fought off the jitters on the third race of the schedule, finishing second a year after suffering a life-threatening injury.

What surprised Canard was what happened next: The mental hurdle was still there.

Instead of just going out and racing, Canard found himself thinking about injuries, wondering if he was going to have another motorcycle land on his back. He went into a funk for the next few races, battling himself as much as the bike or the track.

"I think it really played on him - I don't know if it was the fear or the memory or what," Kari Canard said. "It really weighed on him for the next few races."

But, as he has for most of his life, Canard fought his way through the adversity.

He closed out the Supercross season by winning at Las Vegas and finished sixth in the overall standings.

Canard opened the outdoor season by finishing fourth at the Hangtown Classic in Northern California and was steady most of the way through, finishing fourth overall with a high of second at Spring Creek in Minnesota.

"Trey has a tremendous amount of persistence," said Davey Coombs, vice president of the Lucas Oil Motocross Championships. "For him to have all the injuries and setbacks he's had and keep fighting is pretty incredible."

Not to Canard.

Adversity is a challenge to him, one he's not about to back down from.

Source: Gosanangelo

First Posted: Sep 21, 2013 10:45 AM EDT

UT Southwestern Medical Center researchers have discovered a cellular switch that influences the growth of the commonly diagnosed and aggressive malignant brain tumor.

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The tumor can be switched on and off and its growth restrained with the help of this cellular switch. The researchers found that the RIP1 protein plays a role in destroying or protecting the survival of brain tumor cells. The scientists predict that they can use the protein found in most glioblastomas tumors for creating a drug treatment for such malignancy in the brain.

"Our study identifies a new mechanism involving RIP1that regulates cell division and death in glioblastomas," senior author Dr. Amyn Habib, associate professor of neurology and neurotherapeutics at UT Southwestern, and staff neurologist at VA North Texas Health Care System, stated in a Science Daily report.

"For individuals with glioblastomas, this finding identified a target for the development of a drug treatment option that currently does not exist," Dr.Habib added.

The experimenters utilized animal models in the study for examining the interactions of the RIP1 protein and cell receptor EGFRvIII. Both are used to activate a family of proteins called NFκB, which is crucial for the growth of cancerous tumor cells. The researchers found that when they turned off the RIP1 protein in the experimental model, the NFκB protein and the signaling, which triggers tumor growth reversed too.

Moreover, the researchers also found that activating RIP1 could make the cancer cells enter the death mode themselves.

Around 30 percent of brain tumors are gliomas, a rapidly growing, treatment resistant type of tumor as per to the American Cancer Society. Gliomas include glioblastomas, astrocytomas, ependymomas and oligodendrogliomas.

Source: Scienceworldreport

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